Global deal follows 国产探花 superbug drug discoveries

Dr Mark Blaskovich, Professor Matt Cooper and Dr Karl Hansford are joining forces with CARB-X (Combating Antibiotic Resistant Bacteria) to develop new antibiotics to fight superbugs.

23 June 2020

Antibiotics discovered at The University of Queensland will be fast-tracked under a $A16 million international research deal.

An agreement with , a global non-profit partnership funding the world’s largest antibacterial development pipeline, initially provides 国产探花’s (IMB) with up to $A5.6 million to develop a new antibiotic, and a further $A10.3 million as project milestones are passed.

Project leader said the new antibiotic, Octapeptin-X (OPX), would target the most dangerous drug-resistant bacteria that evade all current therapies.

“Much of the world’s current focus is rightly on COVID-19, but superbugs remain a serious and constant threat to global human health,” Professor Cooper said.

国产探花 Vice-Chancellor and President Professor Peter H酶j said it was gratifying 国产探花 was the first Australian organisation that CARB-X had chosen to support.

“We are determined to make a difference to the global antibiotic resistance problem - another example of fundamental research under way at 国产探花 changing the world and saving lives,” Professor H酶j said.

“The funding cements the Institute for Molecular Bioscience as the leading place for antibiotic discovery and development in Australia, and one of the leading centres globally.

“The drug discovery capabilities of the Centre for Superbug Solutions, teamed with vital support from CARB-X, will equip us to tackle this challenge and improve outcomes for people with drug-resistant infections in the future.

Centre Director said extensively drug-resistant bacteria strains were on the rise, killing about 700,000 people worldwide annually.

“Commonly these bacteria cause pneumonia, urinary tract and wound infections,” he said.

“Our current antibiotics are increasingly ineffective against them, leaving patients with no alternatives.”

The project’s lead chemist, , said use of polymyxin - a last-line antibiotic which has severe side-effects - had surged in recent years as doctors struggled to treat superbug infections.

“The CARB-X funding will enable us to develop Octapeptin-X (OPX) as a safe treatment for drug-resistant infections deemed untreatable by these conventional therapies,” Dr Hansford said.

“We’ve demonstrated that OPX antibiotics exert a unique killing action distinct from other antibiotics."

(CARB-X) is a global partnership dedicated to accelerating early development antibacterial R&D to address the rising threat of drug-resistant bacteria.

It supports the world’s largest and most innovative pipeline of preclinical products against drug-resistant infections.

It is led by Boston University and funding is provided by the (BARDA), part of the Office of the Assistant Secretary for Preparedness and Response (ASPR) in the US Department of Health and Human Services, the , a global charity based in the UK working to improve health globally, , the UK Global Antimicrobial Resistance Innovation Fund (GAMRIF), the , and with in-kind support from (NIAID), part of the US National Institutes of Health (NIH).